Simple Summary Papillary thyroid carcinoma (PTC) represents 80–90% of all differentiated
thyroid carcinomas. PTC has a high rate of gene fusions and mutations, which can influence …

Chromosomes inside the nucleus are not located in the form of linear molecules. Instead,
there is a complex multilevel genome folding that includes nucleosomes packaging …

Classical Hodgkin's lymphoma (cHL) is a B-Cell lymphoma comprised of mononuclear
Hodgkin cells (H) and bi-to multi-nucleated Reed-Sternberg (RS) cells. Previous studies …

Molecular markers can serve as diagnostic tools to support pathological analysis in thyroid
neoplasms. However, because the same markers can be observed in some benign thyroid …

Cell-free DNA (cfDNA) testing, is an emerging “liquid biopsy” tool for noninvasive lymphoma
detection, and an increased amount of data are now available to use this technique with …

Chromosomes are organized in distinct nuclear areas designated as chromosome territories
(CT). The structural formation of CT is a consequence of chromatin packaging and …

Classic Hodgkin lymphoma (cHL) consists of a heterogeneous group of haematological
disorders that covers undifferentiated B cell neoplasms originating from germinal centre B …

Research into the three‐dimensional (3D) organization of the cancer cell genome started
over 100 years ago. We follow an exciting avenue of research in this field, from …

Methods of super-resolving light microscopy (SRM) have found an exponentially growing
range of applications in cell biology, including nuclear structure analyses. Recent …

Recent super-resolution fluorescence microscopy (3D-Structured Illumination Microscopy,
3D-SIM) studies have revealed significantly altered nuclear organization between normal …