From reads to insight: a hitchhiker's guide to ATAC-seq data analysis

F Yan, DR Powell, DJ Curtis, NC Wong - Genome biology, 2020 - Springer
Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

High-throughput single-сell sequencing in cancer research

Q Jia, H Chu, Z Jin, H Long, B Zhu - Signal Transduction and Targeted …, 2022 - nature.com
With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

Modern epigenetics methods in biological research

Y Li - Methods, 2021 - Elsevier
The definition of epigenetics refers that molecular modifications on DNA that can regulate
gene activity are independent of DNA sequence and mitotically stable. Notably, epigenetics …

Epigenetic variation in animal populations: sources, extent, phenotypic implications, and ecological and evolutionary relevance

G Vogt - Journal of Biosciences, 2021 - Springer
Laboratory experiments and fieldwork with asexually reproducing invertebrates and
vertebrates clearly revealed that animal populations can produce substantial phenotypic …

Oxidative stress as a plausible mechanism for zearalenone to induce genome toxicity

YQ Feng, AH Zhao, JJ Wang, Y Tian, ZH Yan, M Dri… - Gene, 2022 - Elsevier
Zearalenone (ZEN), a common non-steroidal estrogenic mycotoxin of the Fusarium genus, is
one of the most frequent and powerful contaminant of grains and cereal products …

[HTML][HTML] Molecular mechanisms underlying the clinical efficacy of panobinostat involve Stochasticity of epigenetic signaling, sensitization to anticancer drugs, and …

N El Omari, S Bakrim, A Khalid, AN Abdalla… - Biomedicine & …, 2023 - Elsevier
Panobinostat, also known as Farydak®, LBH589, PNB, or panobinostat lactate, is a
hydroxamic acid that has been approved by the Food and Drug Administration (FDA) for its …

Small-molecule inhibitors overcome epigenetic reprogramming for cancer therapy

W Xiao, Q Zhou, X Wen, R Wang, R Liu… - Frontiers in …, 2021 - frontiersin.org
Cancer treatment is a significant challenge for the global health system, although various
pharmacological and therapeutic discoveries have been made. It has been widely …

lncRNA XIST induces Aβ accumulation and neuroinflammation by the epigenetic repression of NEP in Alzheimer's disease

XW Yan, HJ Liu, YX Hong, T Meng, J Du… - Journal of …, 2022 - Taylor & Francis
Alzheimer's disease (AD) is the leading cause of dementia globally, but effective treatment is
lacking. We aimed to explore lncRNA XIST role in AD and the mechanisms involved in the …

[HTML][HTML] Molecular mechanistic pathways underlying the anticancer therapeutic efficiency of romidepsin

N El Omari, LH Lee, S Bakrim, HA Makeen… - Biomedicine & …, 2023 - Elsevier
Romidepsin, also known as NSC630176, FR901228, FK-228, FR-901228, depsipeptide, or
Istodax®, is a natural molecule produced by the Chromobacterium violaceum bacterium that …

How Can the Microbiome Induce Carcinogenesis and Modulate Drug Resistance in Cancer Therapy?

I Mendes, N Vale - International Journal of Molecular Sciences, 2023 - mdpi.com
Over the years, cancer has been affecting the lives of many people globally and it has
become one of the most studied diseases. Despite the efforts to understand the cell …