Many common diseases, such as asthma, diabetes or obesity, involve altered interactions
between thousands of genes. High-throughput techniques (omics) allow identification of …

Vertebrates are constantly exposed to pathogens, and the adaptive immunity has most likely
evolved to control and clear such infectious agents. CD4+ T cells are the major players in …

It is coming nowadays more clear that in order to obtain a unified description of the different
mechanisms governing the behavior and causality relations among the various parts of a …

Background Many biological systems are modeled qualitatively with discrete models, such
as probabilistic Boolean networks, logical models, Petri nets, and agent-based models, to …

Johne's disease (JD), a persistent and slow progressing infection of ruminants such as cows
and sheep, is caused by slow replicating bacilli Mycobacterium avium subspecies …

One of the greatest challenges in biomedicine is to get a unified view of observations made
from the molecular up to the organism scale. Towards this goal, multiscale models have …

The immune system is composed of many different cell types and hundreds of intersecting
molecular pathways and signals. This large biological complexity requires coordination …

Drug research, therapy development, and other areas of pharmacology and medicine can
benefit from simulations and optimization of mathematical models that contain a …

An understanding gene-gene interaction helps users to design the next experiments
efficiently and (if applicable) to make a better decision of drugs application based on the …

Background A proper balance between different T helper (Th) cell subsets is necessary for
normal functioning of the adaptive immune system. Revealing key genes and pathways …