Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

The question of how same-gene mutations can drive both cancer and neurodevelopmental
disorders has been puzzling. It has also been puzzling why those with neurodevelopmental …

The Erk mitogen-activated protein kinase plays diverse roles in animal development. Its
widespread reuse raises a conundrum: when a single kinase like Erk is activated, how does …

Signaling by the extracellular signal-regulated kinase (ERK) pathway controls many cellular
processes, including cell division, death, and differentiation. In this second installment of a …

Highlights•Optogenetic techniques are ripe for application to developmental biology.•Light-
activated receptors, gene expression, and clustering work robustly in vivo.•New …

The RASopathies are a group of clinically defined developmental syndromes caused by
germline variants of the RAS/mitogen‐activated protein (MAPK) cascade. The prototypic …

Melorheostosis is a sporadic disease of uncertain etiology characterized by asymmetric
bone overgrowth and functional impairment. Using whole exome sequencing, we identify …

Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling
is critical for the execution of cellular programs and behaviors. Understanding these control …

Optogenetic perturbations, live imaging, and time-resolved ChIP-seq assays in Drosophila
embryos were used to dissect the ERK-dependent control of the HMG-box repressor …

Even amongst genetically identical cancer cells, therapy resistance often only emerges from
a very small subset of those cells. Much effort has gone into uncovering the molecular …