T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …

The chemokine receptor CCR5 has been the focus of intensive studies since its role as a
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …

The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has
hindered our understanding of the initial cells targeted by the virus. Working with the …

While CD4+ T cell depletion is key to disease progression in people living with HIV and SIV-
infected macaques, the mechanisms underlying this depletion remain incompletely …

HIV-1 infection is characterized by varying degrees of chronic immune activation and
disruption of T-cell homeostasis, which impact the rate of disease progression. A deeper …

The ability to persist long term in latently infected CD4 T cells represents a characteristic
feature of HIV-1 infection and the predominant barrier to efforts aiming at viral eradication …

Adaptive immunity requires the generation of memory T cells from naive precursors selected
in the thymus. The key intermediaries in this process are stem cell-like memory T (T SCM) …

In contrast to infections with human immunodeficiency virus (HIV) in humans and simian
immunodeficiency virus (SIV) in macaques, SIV infection of a natural host, sooty mangabeys …

CD4+ T-cell depletion is pathognomonic for AIDS in both HIV and simian immunodeficiency
virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted …

A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain
asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia …