[HTML][HTML] Linking lichen metabolites to genes: emerging concepts and lessons from molecular biology and metagenomics

G Singh - Journal of Fungi, 2023 - mdpi.com
Lichen secondary metabolites have tremendous pharmaceutical and industrial potential.
Although more than 1000 metabolites have been reported from lichens, less than 10 have …

[HTML][HTML] Discovery and excavation of lichen bioactive natural products

M Ren, S Jiang, Y Wang, X Pan, F Pan… - Frontiers in …, 2023 - frontiersin.org
Lichen natural products are a tremendous source of new bioactive chemical entities for drug
discovery. The ability to survive in harsh conditions can be directly correlated with the …

Metagenomics Shines Light on the Evolution of “Sunscreen” Pigment Metabolism in the Teloschistales (Lichen-Forming Ascomycota)

T Llewellyn, RW Nowell, A Aptroot… - Genome Biology and …, 2023 - academic.oup.com
Fungi produce a vast number of secondary metabolites that shape their interactions with
other organisms and the environment. Characterizing the genes underpinning metabolite …

[HTML][HTML] High Diversity of Type I Polyketide Genes in Bacidia rubella as Revealed by the Comparative Analysis of 23 Lichen Genomes

JV Gerasimova, A Beck, S Werth, P Resl - Journal of Fungi, 2022 - mdpi.com
Fungi involved in lichen symbioses produce a large array of secondary metabolites that are
often diagnostic in the taxonomic delimitation of lichens. The most common lichen …

Circadian clock‐and temperature‐associated genes contribute to overall genomic differentiation along elevation in lichenized fungi

HF Valim, FD Grande, ELY Wong… - Molecular Ecology, 2024 - Wiley Online Library
Circadian regulation is linked to local environmental adaptation, and many species with
broad climatic niches display variation in circadian genes. Here, we hypothesize that …

Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A

Q Ji, H Xiang, WG Wang, Y Matsuda - Angewandte Chemie, 2024 - Wiley Online Library
Thielavin A (1) is a fungal depside composed of one 3‐methylorsellinic acid and two 3, 5‐
dimethylorsellinic acid units. It displays diverse biological activities. However, the …

[HTML][HTML] Biosynthetic Potential of Hypogymnia Holobionts: Insights into Secondary Metabolite Pathways

N Ahmad, M Ritz, A Calchera, J Otte, I Schmitt… - Journal of Fungi, 2023 - mdpi.com
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and
a mycobiont (fungus). They are known to produce a variety of unique secondary metabolites …

[HTML][HTML] Genome mining as a biotechnological tool for the discovery of novel biosynthetic genes in lichens

G Singh, F Dal Grande, I Schmitt - Frontiers in Fungal Biology, 2022 - frontiersin.org
Natural products (NPs) and their derivatives are a major contributor to modern medicine.
Historically, microorganisms such as bacteria and fungi have been instrumental in …

[HTML][HTML] Tridepsides as potential bioactives: a review on their chemistry and the global distribution of their lichenic and non-lichenic natural sources

H Norouzi, M Sohrabi, M Yousefi… - Frontiers in Fungal …, 2023 - frontiersin.org
Tridepsides, as fully oxidized polyketides, have been known to exist in lichens for more than
a century. Recent studies have showed that these possible defensive lichenochemicals …

Biosynthetic gene cluster synteny: Orthologous polyketide synthases in Hypogymnia physodes, Hypogymnia tubulosa, and Parmelia sulcata

N Ahmad, M Ritz, A Calchera, J Otte, I Schmitt… - …, 2023 - Wiley Online Library
Lichens are symbiotic associations consisting of a photobiont (algae or cyanobacteria) and
a mycobiont (fungus), which together generate a variety of unique secondary metabolites …