Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
Design, synthesis, anticancer activity and molecular docking of novel 1H-benzo [d] imidazole derivatives as potential EGFR inhibitors
CE Theodore, G Sivaiah, SBB Prasad… - Journal of Molecular …, 2023 - Elsevier
Here, we present the design, synthesis, and evaluation of a new series of 1H-benzo [d]
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …
Design and synthesis of novel benzimidazole linked thiazole derivatives as promising inhibitors of drug-resistant tuberculosis
Despite combination therapy is effective in treating tuberculosis (TB) caused by susceptible
Mycobacterium tuberculosis (Mtb) strains, overcoming multidrug resistance (MDR) remains …
Mycobacterium tuberculosis (Mtb) strains, overcoming multidrug resistance (MDR) remains …
Design, synthesis and molecular docking studies of imidazole and benzimidazole linked ethionamide derivatives as inhibitors of InhA and antituberculosis agents
To explore effective antituberculosis agents, a new class of imidazoles and benzimidazoles
linked ethionamide analogs were designed and synthesized. The elemental analysis, 1 H …
linked ethionamide analogs were designed and synthesized. The elemental analysis, 1 H …
Synthesis, anticancer activity and molecular docking of new pyrazolo [1, 5-a] pyrimidine derivatives as EGFR/HER2 dual kinase inhibitors
G Sivaiah, R Raveesha, SBB Prasad, KY Kumar… - Journal of Molecular …, 2023 - Elsevier
Abstract The pyrazolo [1, 5-a] pyrimidine core framework is a good starting point for the
synthesis of drug-like molecules since the biological activity is determined by the kind and …
synthesis of drug-like molecules since the biological activity is determined by the kind and …
Design, synthesis and molecular docking studies of 5, 6-difluoro-1H-benzo [d] imidazole derivatives as effective binders to GABAA receptor with potent anticonvulsant …
In the search for more effective and safer antiepileptic drugs, a series of 5, 6-difluoro-1H-
benzo [d] imidazole derivatives (4a-e) were designed and synthesized. Elemental analysis …
benzo [d] imidazole derivatives (4a-e) were designed and synthesized. Elemental analysis …
Synthesis, enzyme inhibition and molecular docking studies of pyrazolo [1, 5-a][1, 3, 5] triazine derivatives as potential antioxidant agents
We developed and produced a series of pyrazolo [1, 5-a][1, 3, 5] triazine derivatives (5a-l) in
three stages using condensation, intramolecular ring annulation, and acylation processes …
three stages using condensation, intramolecular ring annulation, and acylation processes …
Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents
Triazine-linked triazole compounds (4a-j) were designed, synthesized, and then examined
for their anticonvulsant abilities. Compounds 4e, 4f, 4g, 4i, and 4j displayed significant …
for their anticonvulsant abilities. Compounds 4e, 4f, 4g, 4i, and 4j displayed significant …
Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants
WH Abd-Allah, MS Abd El-Maksoud… - Medicinal Chemistry …, 2024 - Springer
Aiming to develop novel anticonvulsant agents a new series of novel
cycloalkanecarboxamide parabanic acid hybrids series 8, 9 and 10 possessing the essential …
cycloalkanecarboxamide parabanic acid hybrids series 8, 9 and 10 possessing the essential …
Synthesis, computational and antimicrobial study of 2-(2-Hydrazinyl) thiazole derivatives
RA Shinde, VA Adole, BS Jagdale - Journal of Molecular Structure, 2024 - Elsevier
In the present investigation, we report a combined computational and experimental study of
eight thiazole derivatives (4a-4h) obtained from 3, 4-dihydronaphthalen-1 (2H)-one. A green …
eight thiazole derivatives (4a-4h) obtained from 3, 4-dihydronaphthalen-1 (2H)-one. A green …