A fundamental concept in immunology is that the innate immune system initiates or instructs
downstream adaptive immune responses. Inflammasomes are central players in innate …

Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …

Recently, there has been a substantial increase in the number of studies focused upon
connecting the gut microbiome with cases of central nervous system (CNS) autoimmunity …

TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of
proteins. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals …

The human gastrointestinal microbiota, also known as the gut microbiota living in the human
gastrointestinal tract, has been shown to have a significant impact on several human …

Cognate interaction between CD4+ effector memory T (T EM) cells and dendritic cells (DCs)
induces innate inflammatory cytokine production, resulting in detrimental autoimmune …

Prior infection can generate protective immunity against subsequent infection, although the
efficacy of such immunity can vary considerably. Live-attenuated vaccines (LAVs) are one of …

Highlights•Myeloid cells sense and integrate numerous pathogen-derived signals leading to
priming of a tailored Th cell response.•Dendritic cells are critical nodes of pathogen-derived …

The innate immune system detects pathogens and initiates adaptive immune responses.
Inflammasomes are central components of the innate immune system, but whether …

TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are
members of the TNF and TNFR superfamilies, respectively, with recognised roles in …