Fluorescent nanoparticles for super-resolution imaging

W Li, GS Kaminski Schierle, B Lei, Y Liu… - Chemical …, 2022 - ACS Publications
Super-resolution imaging techniques that overcome the diffraction limit of light have gained
wide popularity for visualizing cellular structures with nanometric resolution. Following the …

Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

The spatial organization of transcriptional control

A Hafner, A Boettiger - Nature Reviews Genetics, 2023 - nature.com
In animals, the sequences for controlling gene expression do not concentrate just at the
transcription start site of genes, but are frequently thousands to millions of base pairs distal …

Quantum-enhanced nonlinear microscopy

CA Casacio, LS Madsen, A Terrasson, M Waleed… - Nature, 2021 - nature.com
The performance of light microscopes is limited by the stochastic nature of light, which exists
in discrete packets of energy known as photons. Randomness in the times that photons are …

Xanthene, cyanine, oxazine and BODIPY: the four pillars of the fluorophore empire for super-resolution bioimaging

S Samanta, K Lai, F Wu, Y Liu, S Cai, X Yang… - Chemical Society …, 2023 - pubs.rsc.org
In the realm of biological research, the invention of super-resolution microscopy (SRM) has
enabled the visualization of ultrafine sub-cellular structures and their functions in live cells at …

The role of 3D genome organization in development and cell differentiation

H Zheng, W Xie - Nature reviews Molecular cell biology, 2019 - nature.com
In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

MINFLUX nanometer-scale 3D imaging and microsecond-range tracking on a common fluorescence microscope

R Schmidt, T Weihs, CA Wurm, I Jansen… - Nature …, 2021 - nature.com
The recently introduced minimal photon fluxes (MINFLUX) concept pushed the resolution of
fluorescence microscopy to molecular dimensions. Initial demonstrations relied on custom …

Tutorial: guidance for quantitative confocal microscopy

J Jonkman, CM Brown, GD Wright, KI Anderson… - Nature protocols, 2020 - nature.com
When used appropriately, a confocal fluorescence microscope is an excellent tool for
making quantitative measurements in cells and tissues. The confocal microscope's ability to …

Single multimode fibre for in vivo light-field-encoded endoscopic imaging

Z Wen, Z Dong, Q Deng, C Pang, CF Kaminski, X Xu… - Nature …, 2023 - nature.com
Super-resolution microscopy is typically not applicable to in situ imaging through a narrow
channel due to the requirement for complex optics. Although multimode fibres (MMFs) have …