Seasonality patterns are reported in various psychiatric disorders. The current paper
summarizes findings on brain adaptations associated with seasonal changes, factors that …

The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …

Insomnia represents a significant public health burden, with a 10% prevalence in the
general population. Reduced sleep affects social and working functioning, productivity, and …

The treatment of bipolar disorder (BD) still remains a challenge. Melatonin (MLT), acting
through its two receptors MT 1 and MT 2, plays a key role in regulating circadian rhythms …

Traumatic brain injury (TBI) is one of the most prevalent causes of morbidity in the United
States and is associated with numerous chronic sequelae long after the point of injury. One …

Bipolar disorders (BDs) are a heterogeneous group of severe affective disorders generally
described by the alternation of (hypo) manic, depressive, and mixed phases, with euthymic …

Background Night shift workers are more susceptible to circadian rhythm disturbances due
to their prolonged exposure to nighttime light. This exposure during abnormal periods …

Melatonin (MLT), a main product of pineal gland, recently has attracted the attention of
scientists due to its benefits in various diseases and also regulation of cellular homeostasis …

The purpose of this study was to investigate the sedative effects of Chrysin (CHR) along with
modulatory effects on diazepam (DZP) and flumazenil (FLU) in an animal sleep model …

Circadian system disruption is an essential but poorly understood feature of bipolar disorder
(BD) and associated comorbidities. This forum article summarizes current evidence …