Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …

Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …

Lymph node follicles capture and retain antigens to induce germinal centers and long-lived
humoral immunity. However, control over antigen retention has been limited. Here we …

Recent discoveries implicate the classical complement cascade in normal brain
development and in disease. Complement proteins C1q, C3, and C4 participate in synapse …

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …

Despite numerous attempts over many years to develop an HIV vaccine based on classical
strategies, none has convincingly succeeded to date. A number of approaches are being …

The complement system of innate immunity is important in regulating humoral immunity
largely through the complement receptor CR2, which forms a coreceptor on B cells during …

With the in-depth exploration on cancer therapeutic nanovaccines, increasing evidence
shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit …

Over the past several decades, B cell antigen receptor (BCR)-induced signaling pathways
have been described in extraordinary molecular detail, mainly from studies of B cell …

Fibroblastic reticular cells (FRCs) are known to inhabit T cell–rich areas of lymphoid organs,
where they function to facilitate interactions between T cells and dendritic cells. However, in …