Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

In mammals, male germ cells differentiate from haploid round spermatids to flagella-
containing motile sperm, in a process called spermiogenesis. This process is distinct from …

Silent information Regulators (SIRT1) gene stimulates antioxidants' expression, repairs cells
damaged by oxidative stress (OS), and prevents the cells' dysfunction. In particular, the role …

Spermiogenesis is a complex cellular differentiation process that the germ cells undergo a
distinct morphological change, and the protamines replace the core histones to facilitate …

Background: Bisphenol A (BPA) is an endocrine disrupting chemical widely used in the
manufacture of polycarbonate plastic and epoxy resin to produce a multitude of consumer …

Male germ cells undergo an extreme but fascinating process of chromatin remodeling that
begins in the testis during the last phase of spermatogenesis and continues through …

Sirt1 is a member of the sirtuin family of proteins and has important roles in numerous
biological processes. Sirt1−/− mice display an increased frequency of abnormal …

The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …

Previous studies reported that, with aging, Leydig cell intracellular antioxidants are reduced
in concentration and intracellular ROS levels increase, suggesting that oxidant/antioxidant …

In the last 40 years, male reproductive health—which is very sensitive to both environmental
exposure and metabolic status—has deteriorated and the poor sperm quality observed has …