Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …

Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal
and other related products, which play an important role in the process of cell death …

Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated
as natural byproducts during cellular processes, including metabolism. Under normal …

Understanding the mechanisms underlying evasive resistance in cancer is an unmet
medical need to improve the efficacy of current therapies. In this study, a combination of …

Cell death can be executed through different subroutines. Since the description of
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …

Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

In eukaryotic cells, macromolecular homeostasis requires selective degradation of damaged
units by the ubiquitin-proteasome system (UPS) and autophagy. Thus, dysfunctional …

Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

As a type of lytic cell death driven by unrestricted lipid peroxidation and subsequent plasma
membrane damage, ferroptosis occurs and develops because of sophisticated signals and …