The cytoplasmic dynein transport machinery and its many cargoes

SL Reck-Peterson, WB Redwine, RD Vale… - … reviews Molecular cell …, 2018 - nature.com
Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

[HTML][HTML] Virology and cell biology of the hepatitis C virus life cycle–An update

J Dubuisson, FL Cosset - Journal of hepatology, 2014 - Elsevier
Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

The interferon-induced transmembrane proteins, IFITM1, IFITM2, and IFITM3 inhibit hepatitis C virus entry

SK Narayana, KJ Helbig, EM McCartney… - Journal of Biological …, 2015 - ASBMB
The interferon-induced transmembrane (IFITM) family of proteins have recently been
identified as important host effector molecules of the type I interferon response against …

[HTML][HTML] Spatiotemporal coupling of the hepatitis C virus replication cycle by creating a lipid droplet-proximal membranous replication compartment

JY Lee, M Cortese, U Haselmann, K Tabata… - Cell reports, 2019 - cell.com
The hepatitis C virus (HCV) is a major cause of chronic liver disease, affecting around 71
million people worldwide. Viral RNA replication occurs in a membranous compartment …

Microtubule regulation and function during virus infection

MH Naghavi, D Walsh - Journal of virology, 2017 - Am Soc Microbiol
Microtubules (MTs) form a rapidly adaptable network of filaments that radiate throughout the
cell. These dynamic arrays facilitate a wide range of cellular processes, including the …

Hepatitis C virus NS5A: enigmatic but still promiscuous 10 years on!

D Ross-Thriepland, M Harris - Journal of General …, 2015 - microbiologyresearch.org
Since one of us co-authored a review on NS5A a decade ago, the hepatitis C virus (HCV)
field has changed dramatically, primarily due to the advent of the JFH-1 cell culture …

[PDF][PDF] Ubiquitin‐specific peptidase 10 (USP10) inhibits hepatic steatosis, insulin resistance, and inflammation through Sirt6

P Luo, C Qin, L Zhu, C Fang, Y Zhang, H Zhang… - …, 2018 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance and inflammation, and the pathogenic mechanism of NAFLD is poorly …

Unconventional RNA‐binding proteins step into the virus–host battlefront

M Garcia‐Moreno, AI Järvelin… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
The crucial participation of cellular RNA‐binding proteins (RBPs) in virtually all steps of virus
infection has been known for decades. However, most of the studies characterizing this …

WTAP Targets the METTL3 m6A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection

MT Sacco, KM Bland, SM Horner - Journal of virology, 2022 - Am Soc Microbiol
Modification of the hepatitis C virus (HCV) positive-strand RNA genome by N6-
methyladenosine (m6A) regulates the viral life cycle. This life cycle takes place solely in the …

Mature lipid droplets are accessible to ER luminal proteins

S Mishra, R Khaddaj, S Cottier… - Journal of Cell …, 2016 - journals.biologists.com
Lipid droplets are found in most organisms where they serve to store energy in the form of
neutral lipids. They are formed at the endoplasmic reticulum (ER) membrane where the …