Aspergillus niger citric acid accumulation: do we understand this well working black box?

L Karaffa, CP Kubicek - Applied microbiology and biotechnology, 2003 - Springer
Abstract This Mini-Review summarizes the current knowledge on the biochemical and
physiological events leading to massive citric acid accumulation by Aspergillus niger under …

Organic acids: old metabolites, new themes

I Goldberg, JS Rokem, O Pines - Journal of Chemical …, 2006 - Wiley Online Library
Fumaric, l‐malic and citric acids are intermediates of the oxidative tricarboxylic acid (TCA)
cycle which in eukaryotes is localized in mitochondria. These organic acids are synthesized …

Sustainable carbon sources for microbial organic acid production with filamentous fungi

S Dörsam, J Fesseler, O Gorte, T Hahn, S Zibek… - Biotechnology for …, 2017 - Springer
Background The organic acid producer Aspergillus oryzae and Rhizopus delemar are able
to convert several alternative carbon sources to malic and fumaric acid. Thus, carbohydrate …

Microbial biosynthesis of L-malic acid and related metabolic engineering strategies: advances and prospects

Z Wei, Y Xu, Q Xu, W Cao, H Huang… - Frontiers in Bioengineering …, 2021 - frontiersin.org
Malic acid, a four-carbon dicarboxylic acid, is widely used in the food, chemical and medical
industries. As an intermediate of the TCA cycle, malic acid is one of the most promising …

Citric acid production

M Berovic, M Legisa - Biotechnology annual review, 2007 - Elsevier
Citric acid is a commodity chemical produced and consumed throughout The World. It is
used mainly in the food and beverage industry, primarily as an acidulant. Although it is one …

Morphology and productivity of filamentous fungi

LH Grimm, S Kelly, R Krull, DC Hempel - Applied microbiology and …, 2005 - Springer
Cultivation processes involving filamentous fungi have been optimised for decades to obtain
high product yields. Several bulk chemicals like citric acid and penicillin are produced this …

Addressing recall bias in (post-) conflict data collection and analysis: lessons from a large-scale health survey in Colombia

R Moreno-Serra, M Anaya-Montes, S León-Giraldo… - Conflict and …, 2022 - Springer
Background Much applied research on the consequences of conflicts for health suffers from
data limitations, particularly the absence of longitudinal data spanning pre-, during-and post …

A deficiency of manganese ions in the presence of high sugar concentrations is the critical parameter for achieving high yields of itaconic acid by Aspergillus terreus

L Karaffa, R Díaz, B Papp, E Fekete, E Sándor… - Applied microbiology …, 2015 - Springer
Itaconic acid (IA), an unsaturated dicarboxylic acid with a high potential as a platform for
chemicals derived from sugars, is industrially produced by large-scale submerged …

Engineering primary metabolic pathways of industrial micro-organisms

A Kern, E Tilley, IS Hunter, M Legiša, A Glieder - Journal of biotechnology, 2007 - Elsevier
Metabolic engineering is a powerful tool for the optimisation and the introduction of new
cellular processes. This is mostly done by genetic engineering. Since the introduction of this …

Regulation of low-molecular weight organic acid production in fungi

C Plassard, P Fransson - Fungal biology reviews, 2009 - Elsevier
Organic acids produced by fungi have been proposed to have many roles in wood-decay
processes, lignocellulose degradation or plant pathogenesis involving saprotrophic or …