Methotrexate (MTX) is the first line drug for the treatment of a number of rheumatic and non-
rheumatic disorders. It is currently used as an anchor disease, modifying anti-rheumatic drug …

The major hallmark of cellular senescence is an irreversible cell cycle arrest and thus it is a
potent tumor suppressor mechanism. Genotoxic insults, eg oxidative stress, are important …

Objective: Neutrophil extracellular traps (NETs) produced by tumor-infiltrating neutrophils
(TINs) are associated with poor prognosis in patients with several types of cancer. However …

Problem Inflammation and infection play a major role in preterm birth. The purpose of this
study was to (i) determine the prevalence and clinical significance of sterile intra‐amniotic …

Background Gout is a prevalent inflammatory arthritis affecting 1–2% of adults characterized
by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the …

Endometriosis, a common cause of pelvic pain and female infertility, depends on the growth
of vascularized endometrial tissue at ectopic sites. Endometrial fragments reach the …

Cellular stress increases progressively with aging in mammalian tissues. Chronic stress
triggers several signaling cascades that can induce a condition called cellular senescence …

Introduction: The objectives of this study were: 1) to determine the amniotic fluid (AF)
microbiology of patients with the diagnosis of clinical chorioamnionitis at term using both …

High mobility group box-1 (HMGB1) is an endogenous danger signal or alarmin that
mediates activation of the innate immune response including chemotaxis and pro …

Astrocytes are the largest group of glial cells in the brain and participate in several essential
functions of the central nervous system (CNS). Disruption of their normal physiological …