This paper is the outcome of the fourth UC Davis Systems Approach to Understanding
Cardiac Excitation–Contraction Coupling and Arrhythmias Symposium, a biannual event …

Myokit is a new powerful and versatile software tool for modeling and simulation of cardiac
cellular electrophysiology. Myokit consists of an easy-to-read modeling language, a …

The light responses of rod and cone photoreceptors have been studied
electrophysiologically for decades, largely with ex vivo approaches that disrupt the …

In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …

Preclinical assessment of drug-induced proarrhythmicity is typically evaluated by the
potency of the drug to block the potassium human ether-à-go-go-related gene (hERG) …

Drug-induced long QT syndrome (diLQTS) is the phenomenon by which the administration
of drugs causes prolongation of cardiac repolarisation and leads to an increased risk of the …

Objective: The hERG potassium channel plays a fundamental role in controlling electrical
activity in the heart and many other tissues. There is a well-established link between hERG …

The hERG (human ether-a-go-go-related gene) encoded potassium ion (K+) channel plays
a major role in cardiac repolarization. Drug-induced blockade of hERG has been a major …

Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with increased risk
of cerebrovascular stroke, and with several other pathologies, including heart failure …

Abstract Introduction The Comprehensive in vitro Proarrhythmic Assay (CiPA) aims to
update current cardiac safety testing to better evaluate arrhythmic risk. A central theme of …