Emerging role of tumor cell plasticity in modifying therapeutic response

S Qin, J Jiang, Y Lu, EC Nice, C Huang… - Signal transduction and …, 2020 - nature.com
Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Cancer stem cells in progression of colorectal cancer

Y Zhou, L Xia, H Wang, L Oyang, M Su, Q Liu… - …, 2017 - pmc.ncbi.nlm.nih.gov
Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant
metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a …

The key roles of cancer stem cell-derived extracellular vesicles

C Su, J Zhang, Y Yarden, L Fu - Signal transduction and targeted …, 2021 - nature.com
Cancer stem cells (CSCs), the subpopulation of cancer cells, have the capability of
proliferation, self-renewal, and differentiation. The presence of CSCs is a key factor leading …

An M0 macrophage-related prognostic model for hepatocellular carcinoma

Y Zhang, J Zou, R Chen - BMC cancer, 2022 - Springer
Background The role of M0 macrophages and their related genes in the prognosis of
hepatocellular carcinoma (HCC) remains poorly characterized. Methods Multidimensional …

Hypoxia induced β-catenin lactylation promotes the cell proliferation and stemness of colorectal cancer through the wnt signaling pathway

Z Miao, X Zhao, X Liu - Experimental cell research, 2023 - Elsevier
Colorectal cancer (CRC) is a common malignant tumor of digestive system. Its incidence
rate and mortality rate ranks the third among all the malignant tumors. The objective of this …

Enterotoxigenic Bacteroides fragilis induces the stemness in colorectal cancer via upregulating histone demethylase JMJD2B

QQ Liu, CM Li, LN Fu, HL Wang, J Tan, YQ Wang… - Gut …, 2020 - Taylor & Francis
ABSTRACT The enrichment of Enterotoxigenic Bacteroides fragilis (ETBF) has been
identified in CRC patients and associated with worse prognosis. Cancer stem cells (CSCs) …

Ginsenoside Rg3 targets cancer stem cells and tumor angiogenesis to inhibit colorectal cancer progression in vivo

YC Tang, Y Zhang, J Zhou, Q Zhi… - International …, 2018 - spandidos-publications.com
Anti-angiogenic therapy has been successfully applied to treat colorectal cancer (CRC).
Ginsenoside Rg3, derived from the Chinese herb ginseng, has anti-vascularization effects …

[HTML][HTML] miR-302a inhibits metastasis and cetuximab resistance in colorectal cancer by targeting NFIB and CD44

L Sun, Y Fang, X Wang, Y Han, F Du, C Li, H Hu… - Theranostics, 2019 - ncbi.nlm.nih.gov
Introduction: Metastasis and drug resistance contribute substantially to the poor prognosis of
colorectal cancer (CRC) patients. However, the epigenetic regulatory mechanisms by which …

Curcumin suppresses LGR5 (+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway

X Mao, X Zhang, X Zheng, Y Chen, Z Xuan… - Journal of natural …, 2021 - Springer
Colorectal cancer stem cells (CSCs) have the potential for self-renewal, proliferation, and
differentiation. And LGR5 is a stem cell marker gene of colorectal cancer. Curcumin can …

Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening

Z Luo, B Wang, F Luo, Y Guo, N Jiang, J Wei, X Wang… - BMC medicine, 2023 - Springer
Background Colorectal adenoma (CA), especially high-risk CA (HRCA), is a precancerous
lesion with high prevalence and recurrence rate and accounts for about 90% incidence of …