Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement

MCS Boguszewski, CL Boguszewski… - European Journal of …, 2022 - academic.oup.com
Growth hormone (GH) has been used for over 35 years, and its safety and efficacy has been
studied extensively. Experimental studies showing the permissive role of GH/insulin-like …

Advances in differential diagnosis and management of growth hormone deficiency in children

C Hage, HW Gan, A Ibba, G Patti, M Dattani… - Nature Reviews …, 2021 - nature.com
Growth hormone (GH) deficiency (GHD) in children is defined as impaired production of GH
by the pituitary gland that results in growth failure. This disease might be congenital or …

Diagnosis and testing for growth hormone deficiency across the ages: a global view of the accuracy, caveats, and cut-offs for diagnosis

KCJ Yuen, G Johannsson, KKY Ho… - Endocrine …, 2023 - ec.bioscientifica.com
Growth hormone deficiency (GHD) is a clinical syndrome that can manifest either as isolated
or associated with additional pituitary hormone deficiencies. Although diminished height …

Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer

JJ Kopchick, R Basu, DE Berryman… - Nature Reviews …, 2022 - nature.com
Since its discovery nearly a century ago, over 100,000 studies of growth hormone (GH) have
investigated its structure, how it interacts with the GH receptor and its multiple actions. These …

Usefulness and potential pitfalls of long-acting growth hormone analogs

KCJ Yuen, BS Miller, CL Boguszewski… - Frontiers in …, 2021 - frontiersin.org
Daily recombinant human GH (rhGH) is currently approved for use in children and adults
with GH deficiency (GHD) in many countries with relatively few side-effects. Nevertheless …

Insulin-like growth factor-1 levels are associated with high comorbidity of metabolic disorders in obese subjects; a Japanese single-center, retrospective-study

H Kubo, S Sawada, M Satoh, Y Asai, S Kodama… - Scientific Reports, 2022 - nature.com
Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in
adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute …

Hypothalamic-pituitary and other endocrine surveillance among childhood cancer survivors

L Van Iersel, RL Mulder, C Denzer, LE Cohen… - Endocrine …, 2022 - academic.oup.com
Endocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers
are associated with substantial adverse physical and psychosocial effects. To improve …

Investigation of pituitary functions after acute coronavirus disease 2019

E Urhan, Z Karaca, GK Unuvar, K Gundogan… - Endocrine …, 2022 - jstage.jst.go.jp
Abstract Although coronavirus disease 2019 (COVID-19) mainly involves the lungs, it also
affects many systems. The hypothalamic/pituitary axis is vulnerable to hypoxia …

[PDF][PDF] Growth hormone deficiency and NAFLD: An overlooked and underrecognized link

I Doycheva, D Erickson, KD Watt - Hepatology Communications, 2022 - Wiley Online Library
Growth hormone and its mediator insulin‐like growth factor‐1 exert their effect on different
organs and control various physiologic metabolic processes. Adult growth hormone …

Once-weekly somapacitan is effective and well tolerated in adults with GH deficiency: a randomized phase 3 trial

G Johannsson, MB Gordon… - The Journal of …, 2020 - academic.oup.com
Context Growth hormone (GH) replacement requires daily GH injections, which is
burdensome for some adult patients with GH deficiency (AGHD). Objective To demonstrate …