Gliomas are amongst the most insidious and destructive types of brain cancer and are
associated with a poor prognosis, frequent recurrences, and extremely high lethality despite …

Despite advances in understanding of the molecular pathogenesis of glioma, outcomes
remain dismal. Developing successful treatments for glioma requires faithful in vivo disease …

Background Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in
adults. Recent research on cancer stroma indicates that the brain microenvironment plays a …

The identification and significance of cancer stem-like cells in malignant gliomas remains
controversial. It has been proposed that cancer stem-like cells display increased drug …

Cancer-associated fibroblasts (CAFs) significantly influence biological properties of many
tumors. The role of these mesenchymal cells is also anticipated in human gliomas. To …

Simple Summary We review here what is currently known about the role of mesenchymal
stromal-like cells, which complicate our understanding of the glioma microenvironment. We …

Members of the nuclear factor of activated T cells (NFAT) family have been identified as
regulators of oncogenic transformation in several human malignancies. A prominent …

Resistance to antiangiogenic therapy in glioblastoma (GBM) patients may involve hypoxia-
induced expression of CXC motif chemokine receptor 4 (CXCR4) on invading tumor cells …

Gliomas are aggressive brain tumours that, despite advances in multimodal therapies,
continue to portend a dismal prognosis. Glioblastoma multiforme (GBM) represents the most …

Oncolytic virotherapy represents a promising approach for treating recurrent and/or drug-
resistant ovarian cancer. However, its successful application in the clinic has been …