Alternative splicing is commonly believed to be a major source of cellular protein diversity.
However, although many thousands of alternatively spliced transcripts are routinely detected …

Abstract The APPRIS database (http://appris-tools. org) uses protein structural and functional
features and information from cross-species conservation to annotate splice isoforms in …

Abstract APPRIS (https://appris. bioinfo. cnio. es) is a well-established database housing
annotations for protein isoforms for a range of species. APPRIS selects principal isoforms …

The HUPO Human Proteome Project (HPP) has two overall goals:(1) stepwise completion of
the protein parts list the draft human proteome including confidently identifying and …

Alternative splicing of messenger RNA can generate an array of mature transcripts, but it is
not clear how many go on to produce functionally relevant protein isoforms. There is only …

Mapping gene interactions within tissues/cell types plays a crucial role in understanding the
genetic basis of human physiology and disease. Tissue functional gene networks (FGNs) …

Intron retention (IR) has been implicated in the pathogenesis of complex diseases such as
cancers; its association with Alzheimer's disease (AD) remains unexplored. We performed …

Motivation Selecting the splice variant that best represents a coding gene is a crucial first
step in many experimental analyses, and vital for mapping clinically relevant variants. This …

Background The classic central dogma in biology is the information flow from DNA to mRNA
to protein, yet complicated regulatory mechanisms underlying protein translation often lead …

The vast majority of human multiexon genes undergo alternative splicing and produce a
variety of splice variant transcripts and proteins, which can perform different functions. These …