The first objective is to highlight the lack of tools to measure whether a given intervention
affords neuroprotection in patients with Alzheimer's or Parkinson's diseases. A second aim is …

The interaction between metabolic dysfunction and inflammation is central to the
development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's …

Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …

Obesity is a major modifiable risk factor leading to neuroinflammation and
neurodegeneration. Excessive fat storage in obesity promotes the progressive infiltration of …

Overcoming the blood–brain barrier (BBB) remains a significant hurdle in effective drug
delivery to the brain. While the BBB serves as a crucial protective barrier, it poses …

Background Parkinson's disease (PD) is a prevalent neurodegenerative disorder
characterized by the progressive loss of dopaminergic neurons. This study aims to discover …

Background Tumor necrosis factor (TNF) receptor 1 (TNFR1) signaling mediates neuronal
necroptosis in Alzheimer's disease (AD). Interaction of TNFR1 signaling axis with …

Aim: An analysis of bioinformatics and cell experiments was performed to verify the
relationship between gasdermin D (GSDMD), an executive protein of pyroptosis, and …

The increasing prevalence of Alzheimer's disease in older adults has raised significant
concern in recent years. Aware of this challenge, this research set out to develop predictive …

In this research, after data preparation, disease prediction has been attempted using large
matrix methods and data mining techniques. By examining the new vector, we can find out …