Gut microbiota metabolites in NAFLD pathogenesis and therapeutic implications

J Chen, L Vitetta - International journal of molecular sciences, 2020 - mdpi.com
Gut microbiota dysregulation plays a key role in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through its metabolites. Therefore, the restoration of the gut microbiota and …

The role of gut microbiota in some liver diseases: from an immunological perspective

L Wang, ZM Cao, LL Zhang, J Li, W Lv - Frontiers in immunology, 2022 - frontiersin.org
Gut microbiota is a microecosystem composed of various microorganisms. It plays an
important role in human metabolism, and its metabolites affect different tissues and organs …

[HTML][HTML] Understanding the cellular interactome of non-alcoholic fatty liver disease

SJ Wallace, F Tacke, RF Schwabe, NC Henderson - JHEP Reports, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is reaching epidemic proportions, with a global
prevalence of 25% in the adult population. Non-alcoholic steatohepatitis (NASH), which can …

Role of microbiota-derived metabolites in alcoholic and non-alcoholic fatty liver diseases

JW Park, SE Kim, NY Lee, JH Kim, JH Jung… - International Journal of …, 2021 - mdpi.com
Chronic liver disease encompasses diseases that have various causes, such as alcoholic
liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Gut microbiota …

[HTML][HTML] Animal models of fibrosis in nonalcoholic steatohepatitis: do they reflect human disease?

DH Ipsen, J Lykkesfeldt, P Tveden-Nyborg - Advances in Nutrition, 2020 - Elsevier
Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases in
the world, yet no pharmacotherapies are available. The lack of translational animal models …

Aflatoxin B1 induces intestinal barrier dysfunction by regulating the FXR-mediated MLCK signaling pathway in mice and in IPEC-J2 cells

S Liu, J Li, W Kang, Y Li, L Ge, D Liu… - Journal of agricultural …, 2022 - ACS Publications
Aflatoxin B1 (AFB1) is a widespread mycotoxin in food and feed. Although the liver is the
main target organ of AFB1, the intestine is the first exposure organ to AFB1. However, the …

Role of the gut microbiota in regulating non-alcoholic fatty liver disease in children and adolescents

D Tokuhara - Frontiers in Nutrition, 2021 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
in children and adolescents. Although obesity is the leading cause of NAFLD, the etiologies …

Role of bile acids in overweight and obese children and adolescents

C Giannini, C Mastromauro, S Scapaticci… - Frontiers in …, 2022 - frontiersin.org
Bile acids (BAs) are amphipathic molecules synthetized in the liver. They are primarily
involved in the digestion of nutrients. Apart from their role in dietary lipid absorption, BAs …

The role of the intestinal microbiota in nonalcoholic steatohepatitis

H Xiang, D Sun, X Liu, ZG She, Y Chen - Frontiers in endocrinology, 2022 - frontiersin.org
Nonalcoholic steatohepatitis (NASH) is a serious disease threatening public health, and its
pathogenesis remains largely unclear. Recent scientific research has shown that intestinal …

[HTML][HTML] Roles of immune dysregulation in MASLD

T Dong, J Li, Y Liu, S Zhou, X Wei, H Hua… - Biomedicine & …, 2024 - Elsevier
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common
chronic liver disease worldwide. Its occurrence and progression involve the process from …