MP Gilbert, RE Pratley - Frontiers in endocrinology, 2020 - frontiersin.org
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from enteroendocrine cells in response to the …
R Pratley, A Amod, ST Hoff, T Kadowaki, I Lingvay… - The Lancet, 2019 - thelancet.com
Summary Background Glucagon-like peptide-1 (GLP-1) receptor agonists are effective treatments for type 2 diabetes, lowering glycated haemoglobin (HbA 1c) and weight, but are …
OBJECTIVE Efficacy and safety of the glucagon-like peptide 1 (GLP-1) analog oral semaglutide and the sodium–glucose cotransporter 2 inhibitor empagliflozin were compared …
MA Nauck, JJ Meier, MA Cavender, M Abd El Aziz… - Circulation, 2017 - Am Heart Assoc
Potentiation of glucagon-like peptide-1 (GLP-1) action through selective GLP-1 receptor (GLP-1R) agonism or by prevention of enzymatic degradation by inhibition of dipeptidyl …
A Abramson, MR Frederiksen, A Vegge, B Jensen… - Nature …, 2022 - nature.com
Oral administration provides a simple and non-invasive approach for drug delivery. However, due to poor absorption and swift enzymatic degradation in the gastrointestinal …
MT Larsen, M Kuhlmann, ML Hvam… - Molecular and cellular …, 2016 - Springer
The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific …
Oral administration is perhaps the most commonly used and acceptable route for drug delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …
JM Forbes, ME Cooper - Physiological reviews, 2013 - journals.physiology.org
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required, but also for its major complications, affecting both small and large blood vessels …
A Jorsal, C Kistorp, P Holmager… - European journal of …, 2017 - Wiley Online Library
Aims To determine the effect of the glucagon‐like peptide‐1 analogue liraglutide on left ventricular function in chronic heart failure patients with and without type 2 diabetes …