A comprehensive and systematic review on potential anticancer activities of eugenol: From pre-clinical evidence to molecular mechanisms of action

SN Begum, AS Ray, CH Rahaman - Phytomedicine, 2022 - Elsevier
Abstract Background Eugenol (1-allyl-4-hydroxy-3-methoxybenzene) is an important simple
phenolic compound mainly derived from Syzygium aromaticum and many other plants. It is …

From natural sources to synthetic derivatives: The allyl motif as a powerful tool for fragment-based design in cancer treatment

N Astrain-Redin, C Sanmartin… - Journal of Medicinal …, 2023 - ACS Publications
Since the beginning of history, natural products have been an abundant source of bioactive
molecules for the treatment of different diseases, including cancer. Many allyl derivatives …

Eugenol, a major component of clove oil, attenuates adiposity, and modulates gut microbiota in high‐fat diet‐fed mice

M Li, Y Zhao, Y Wang, R Geng, J Fang… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope Eugenol (EU), the major aromatic compound derived from clove oil, is being focused
recently due to its potential in preventing several chronic conditions. Herein, this study aims …

New natural Eugenol derivatives as antiproliferative agents: synthesis, biological evaluation, and computational studies

S Nazreen, SEI Elbehairi, AM Malebari, N Alghamdi… - ACS …, 2023 - ACS Publications
Semisynthetic modifications of natural products have bestowed us with many anticancer
drugs. In the present work, a natural product, eugenol, has been modified synthetically to …

Molecular mechanisms of action of eugenol in cancer: recent trends and advancement

I Padhy, P Paul, T Sharma, S Banerjee, A Mondal - Life, 2022 - mdpi.com
Background: Cancer is, at present, among the leading causes of morbidity globally. Despite
advances in treatment regimens for cancer, patients suffer from poor prognoses. In this …

The clove (Syzygium aromaticum) genome provides insights into the eugenol biosynthesis pathway

S Ouadi, N Sierro, S Goepfert, L Bovet… - Communications …, 2022 - nature.com
The clove (Syzygium aromaticum) is an important tropical spice crop in global trade.
Evolving environmental pressures necessitate modern characterization and selection …

Integration of molecular docking and in vitro studies: a powerful approach for drug discovery in breast cancer

C Cava, I Castiglioni - Applied Sciences, 2020 - mdpi.com
Molecular docking in the pharmaceutical industry is a powerful in silico approach for
discovering novel therapies for unmet medical needs predicting drug–target interactions. It …

Recent advances in nutritional composition, phytochemistry, bioactive, and potential applications of Syzygium aromaticum L. (Myrtaceae)

Q Xue, Z Xiang, S Wang, Z Cong, P Gao, X Liu - Frontiers in Nutrition, 2022 - frontiersin.org
Syzygium aromaticum is an aromatic plant native to Indonesia, and introduced to tropical
regions worldwide. As an ingredient in perfumes, lotions, and food preservation, it is widely …

Enhancing anti-tumorigenic efficacy of eugenol in human colon cancer cells using enzyme-responsive nanoparticles

N Wijewantha, S Sane, M Eikanger, RM Antony… - Cancers, 2023 - mdpi.com
Simple Summary The migratory and invasive pathways that evolve in the early stage of
colorectal cancer (CRC) are crucial in developing the metastatic cascade and drug …

Design, synthesis and biological evaluation of new eugenol derivatives containing 1, 3, 4-oxadiazole as novel inhibitors of thymidylate synthase

MM Alam, SEI Elbehairi, AA Shati, RA Hussien… - New Journal of …, 2023 - pubs.rsc.org
Natural products and their semi-synthetic analogues have provided many chemotherapeutic
drugs. In the current study, eugenol, a natural anticancer agent, has been modified …