Evolving therapeutic landscape of advanced hepatocellular carcinoma

C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Hepatocellular carcinoma: new developments

P Ganesan, LM Kulik - Clinics in liver disease, 2023 - liver.theclinics.com
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality
worldwide and a leading cause of death in cirrhosis. The prognosis in HCC is poor, with …

The curious case of the HepG2 cell line: 40 years of expertise

VA Arzumanian, OI Kiseleva… - International journal of …, 2021 - mdpi.com
Liver cancer is the third leading cause of cancer death worldwide. Representing such a
dramatic impact on our lives, liver cancer is a significant public health concern. Sustainable …

Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases

JA Marrero, LM Kulik, CB Sirlin, AX Zhu, RS Finn… - Hepatology, 2018 - journals.lww.com
This guidance provides a data-supported approach to the diagnosis, staging, and treatment
of patients diagnosed with hepatocellular carcinoma (HCC). A guidance document is …

Hepatocellular carcinoma immune landscape and the potential of immunotherapies

J Giraud, D Chalopin, JF Blanc, M Saleh - Frontiers in immunology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most common liver tumor and among the deadliest
cancers worldwide. Advanced HCC overall survival is meager and has not improved over …

The current landscape of immune checkpoint blockade in hepatocellular carcinoma: a review

M Pinter, RK Jain, DG Duda - JAMA oncology, 2021 - jamanetwork.com
Importance For more than a decade, sorafenib has been the only systemic treatment option
for patients with advanced hepatocellular carcinoma (HCC). However, rapid progress over …

[HTML][HTML] TGF-β signaling in liver, pancreas, and gastrointestinal diseases and cancer

NR Gough, X Xiang, L Mishra - Gastroenterology, 2021 - Elsevier
Genetic alterations affecting transforming growth factor–β (TGF-β) signaling are
exceptionally common in diseases and cancers of the gastrointestinal system. As a regulator …

Immunomodulatory TGF-β signaling in hepatocellular carcinoma

J Chen, JA Gingold, X Su - Trends in molecular medicine, 2019 - cell.com
Hepatocellular carcinoma (HCC) is an inflammation-induced and chemotherapy-resistant
cancer. Dysregulated signaling in the transforming growth factor beta (TGF-β) pathway plays …

HCCDB: a database of hepatocellular carcinoma expression atlas

Q Lian, S Wang, G Zhang, D Wang… - Genomics …, 2018 - academic.oup.com
Hepatocellular carcinoma (HCC) is highly heterogeneous in nature and has been one of the
most common cancer types worldwide. To ensure repeatability of identified gene expression …

circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma

X Zhang, Y Xu, Z Qian, W Zheng, Q Wu, Y Chen… - Cell death & …, 2018 - nature.com
Some types of circular RNA (circRNA) are aberrantly expressed in human diseases
including hepatocellular carcinoma (HCC). However, its regulation mechanism and …