Endogenous retroelements as alarms for disruptions to cellular homeostasis

HT Lindholm, R Chen, DD De Carvalho - Trends in Cancer, 2023 - cell.com
Endogenous retroelements are DNA sequences which can duplicate and move to new
locations in the genome. Actively moving endogenous retroelements can be disruptive to the …

RNA-binding protein signaling in adult neurogenesis

JNM Chan, DI Sánchez-Vidaña… - Frontiers in Cell and …, 2022 - frontiersin.org
The process of neurogenesis in the brain, including cell proliferation, differentiation, survival,
and maturation, results in the formation of new functional neurons. During embryonic …

The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events

S Almasi, BJ Jasmin - Cellular and Molecular Life Sciences, 2021 - Springer
The double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially
discovered in insects as a regulator of mRNA localization. Later, its mammalian orthologs …

The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation

H Ramos, A Monette, M Niu, A Barrera… - Nucleic Acids …, 2022 - academic.oup.com
Translation initiation of the viral genomic mRNA (vRNA) of human immunodeficiency virus-
type 1 (HIV-1) can be mediated by a cap-or an internal ribosome entry site (IRES) …

[HTML][HTML] Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function

F Niu, Z Li, Y Ren, Z Li, H Guan, Y Li, Y Zhang, Y Li… - Redox Biology, 2023 - Elsevier
Vascular endothelial cells (ECs) senescence plays a crucial role in vascular aging that
promotes the initiation and progression of cardiovascular disease. The mutation of Grb10 …

RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade

Z Lv, Y Ren, Y Li, F Niu, Z Li, M Li, X Li, Q Li… - Molecular …, 2024 - Springer
Background Obesity is well-established as a significant contributor to the development of
insulin resistance (IR) and diabetes, partially due to elevated plasma saturated free fatty …

Staufen1 localizes to the mitotic spindle and controls the localization of RNA populations to the spindle

S Hassine, F Bonnet-Magnaval… - Journal of cell …, 2020 - journals.biologists.com
ABSTRACT Staufen1 (STAU1) is an RNA-binding protein involved in the post-transcriptional
regulation of mRNAs. We report that a large fraction of STAU1 localizes to the mitotic spindle …

High level of Staufen1 expression confers longer recurrence free survival to non-small cell lung cancer patients by promoting THBS1 mRNA degradation

F Bonnet-Magnaval, LH Diallo, V Brunchault… - International Journal of …, 2021 - mdpi.com
Stau1 is a pluripotent RNA-binding protein that is responsible for the post-transcriptional
regulation of a multitude of transcripts. Here, we observed that lung cancer patients with a …

A degradation motif in STAU1 defines a novel family of proteins involved in inflammation

Y Gonzalez Quesada, L DesGroseillers - International Journal of …, 2022 - mdpi.com
Cancer development is regulated by inflammation. Staufen1 (STAU1) is an RNA-binding
protein whose expression level is critical in cancer cells as it is related to cell proliferation or …

The S taufen 1‐dependent cell cycle regulon or how a misregulated RNA‐binding protein leads to cancer

F Bonnet‐Magnaval, L DesGroseillers - Biological Reviews, 2021 - Wiley Online Library
In recent years, an increasing number of reports have linked the RNA‐binding protein
Staufen1 (STAU1) to the control of cell decision making. In non‐transformed cells, STAU1 …