A framework for understanding the functions of biomolecular condensates across scales
AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …
Control of DNA replication timing in the 3D genome
The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …
Condensed but liquid-like domain organization of active chromatin regions in living human cells
In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …
domains, for various cellular functions. However, their physical nature in living cells remains …
Condensed chromatin behaves like a solid on the mesoscale in vitro and in living cells
The association of nuclear DNA with histones to form chromatin is essential for temporal and
spatial control of eukaryotic genomes. In this study, we examined the physical state of …
spatial control of eukaryotic genomes. In this study, we examined the physical state of …
Uncovering an organ's molecular architecture at single-cell resolution by spatially resolved transcriptomics
Revealing fine-scale cellular heterogeneity among spatial context and the functional and
structural foundations of tissue architecture is fundamental within biological research and …
structural foundations of tissue architecture is fundamental within biological research and …
Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II
Although chromatin organization and dynamics play a critical role in gene transcription, how
they interplay remains unclear. To approach this issue, we investigated genome-wide …
they interplay remains unclear. To approach this issue, we investigated genome-wide …
Dynamic chromatin organization without the 30-nm fiber
K Maeshima, S Ide, M Babokhov - Current opinion in cell biology, 2019 - Elsevier
Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones,
and various associated proteins. Over the past ten years, our view of chromatin has shifted …
and various associated proteins. Over the past ten years, our view of chromatin has shifted …
Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling
Guanine-rich DNA sequences occur throughout the human genome and can transiently form
G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic …
G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic …
The solid and liquid states of chromatin
The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …
followed by a comprehensive section on phase separation of chromatin, in which we recount …
Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin
E Miron, R Oldenkamp, JM Brown, DMS Pinto… - Science …, 2020 - science.org
Three-dimensional (3D) chromatin organization plays a key role in regulating mammalian
genome function; however, many of its physical features at the single-cell level remain …
genome function; however, many of its physical features at the single-cell level remain …