The basic features of the life cycle of Trypanosoma cruzi have been known for nearly a
century. Various aspects of the life cycle, however, have been elucidated only recently …

Lactacystin, a microbial natural product that inhibits cell proliferation and induces neurite
outgrowth in a murine neuroblastoma cell line, has become a widely used reagent in …

▪ Abstract Proteases from a variety of protozoan parasites have been characterized at the
molecular and cellular levels, and the many roles that proteases play in these organisms are …

Background Malaria continues to be a devastating parasitic disease that causes the death of
2 million individuals annually. The increase in multi-drug resistance together with the …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Proteasomes degrade most of the proteins inside eukaryotic cells, including transcription
factors and regulators of cell cycle progression. Here we show that nanomolar …

Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, contains
cysteine, serine, threonine, aspartyl and metallo peptidases. The most abundant among …

Autophagy is the major mechanism used by eukaryotic cells to degrade and recycle proteins
and organelles. Bioinformatics analysis of the genome of the protozoan parasite …

Introduction: Parasitic diseases that pose a threat to human life include leishmaniasis–
caused by protozoan parasite Leishmania species. Existing drugs have limitations due to …

The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an
obligate intracellular protozoan pathogen. Overlapping mechanisms ensure successful …