This review focuses on providing insights into the structural basis and clinical relevance of
LFA‐1 and VLA‐4 inhibition by peptides and small molecules as adhesion‐based …

Eosinophilic inflammation is a characteristic feature of asthma. Integrins are highly versatile
cellular receptors that regulate extravasation of eosinophils from the postcapillary segment …

Immunosenescence is the functional deterioration of the immune system during natural
aging. Despite increased susceptibility to bacterial infections in older adults, age-associated …

Background Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults
have significant joint issues leading to poor health. Poor health is compounded by many …

P110δ phosphoinositide 3‐kinase (PI3K) plays a pivotal role in the recruitment and
activation of certain inflammatory cells. Recent findings revealed that the activity of p110δ …

Phosphatase and tensin homologue deleted on chromosome ten (PTEN) is part of a
complex signaling system that affects a variety of important cell functions. PTEN blocks the …

The ligand‐activated nuclear receptor peroxisome proliferator‐activated receptor γ (PPARγ)
has been shown to regulate cell activation, differentiation, proliferation, and/or apoptosis …

Background Dysfunctional neutrophils with advanced age are a hallmark of
immunosenescence. Reduced migration and bactericidal activity increase the risk of …

Neutrophil dysfunction is a common feature of aging, and is associated with the
pathogenesis of many age-related diseases, including type 2 diabetes mellitus (T2DM) …

PGD 2, a major mast cell mediator, is a potent eosinophil chemoattractant and is thought to
be involved in eosinophil recruitment to sites of allergic inflammation. In plasma, PGD 2 is …