The spatial and temporal development of the brain, overlying meninges (fibroblasts,
vasculature and immune cells) and calvarium are highly coordinated. In particular, the timing …

Neural stem cells (NSCs) undergo self-renewal and generate neurons and glial cells under
the influence of specific signals from surrounding environments. Glioblastoma multiforme …

Human cortical organoids (hCOs), derived from human induced pluripotent stem cells
(iPSCs), provide a platform to interrogate mechanisms of human brain development and …

During neocortical development, tight regulation of neurogenesis-to-astrogenesis switching
of neural precursor cells (NPCs) is critical to generate a balanced number of each neural …

The brain consists of three major cell types: neurons and two glial cell types (astrocytes and
oligodendrocytes). Although they are generated from common multipotent neural …

Wound healing of the central nervous system (CNS) is characterized by the classical phases
of 'hemostasis','inflammation','proliferation', and 'remodeling'. Uncontrolled wound healing …

Astrocytes exhibit dynamic and complex reactions to various insults. Recently, investigations
into the transitions that occur during cellular specification, differentiation, maturation, and …

Tissue or organ fibrosis is the pathological scarring that occurs when the wound healing
pathway is dysregulated (ie, the appropriate healing response does not stop and becomes …

The leptomeninges, comprising the inner two layers of the meninges, were traditionally
recognised solely for their protective role in the central nervous system (CNS), yet are now …

The brain consists of three major cell types: neurons and two glial cell types (astrocytes and
oligodendrocytes). Although they are generated from common multipotent neural …