[HTML][HTML] Rap1b is required for normal platelet function and hemostasis in mice
M Chrzanowska-Wodnicka, SS Smyth… - The Journal of …, 2005 - Am Soc Clin Investig
Rap1b, an abundant small GTPase in platelets, becomes rapidly activated upon stimulation
with agonists. Though it has been implicated to act downstream from G protein–coupled …
with agonists. Though it has been implicated to act downstream from G protein–coupled …
Relationships between Rap1b, affinity modulation of integrin αIIbβ3, and the actin cytoskeleton
A Bertoni, S Tadokoro, K Eto, N Pampori… - Journal of Biological …, 2002 - ASBMB
The affinity of integrin α IIb β 3 for fibrinogen is controlled by inside-out signals that are
triggered by agonists like thrombin. Agonist treatment of platelets also activates Rap1b, a …
triggered by agonists like thrombin. Agonist treatment of platelets also activates Rap1b, a …
Rap1b: A cytoskeletal regulator Advantageous to viral infection
B Zhang, S Li, J Ding, J Guo, Z Ma - Iscience, 2024 - cell.com
RAS-like small GTP-binding protein 1b (Rap1b) is a small GTPase involved in numerous
deformation-mediated physiological processes, including viral infection, though cytoskeleton …
deformation-mediated physiological processes, including viral infection, though cytoskeleton …
The small GTPase Rap1 is activated by turbulence and is involved in integrin αIIbβ3-mediated cell adhesion in human megakaryocytes
KMT de Bruyn, FJT Zwartkruis, J de Rooij… - Journal of Biological …, 2003 - ASBMB
The small GTPase Rap1, which is activated by a large variety of stimuli, functions in the
control of integrin-mediated cell adhesion. Here we show that in human megakaryocytes …
control of integrin-mediated cell adhesion. Here we show that in human megakaryocytes …
Tumor cell migration and invasion are enhanced by depletion of Rap1 GTPase-activating protein (Rap1GAP)
OM Tsygankova, H Wang, JL Meinkoth - Journal of Biological Chemistry, 2013 - ASBMB
The functional significance of the widespread down-regulation of Rap1 GTPase-activating
protein (Rap1GAP), a negative regulator of Rap activity, in human tumors is unknown. Here …
protein (Rap1GAP), a negative regulator of Rap activity, in human tumors is unknown. Here …
[PDF][PDF] Tumor cell migration and invasion are
JL Meinkoth, OM Tsygankova, H Wang - 2013 - researchgate.net
Background: Although widespread, the significance of Rap1GAP downregulation in human
tumors is unknown. Results: Genetic silencing of Rap1GAP in human colon cancer cells …
tumors is unknown. Results: Genetic silencing of Rap1GAP in human colon cancer cells …
[PDF][PDF] Ras-like small GTPases in platelet biology
KMT Bruyn - 2002 - core.ac.uk
Ral is a ubiquitously expressed Ras-like small GTPase. Several guanine-nucleotide
exchange factors for Ral have been identified, including members of the RalGDS family …
exchange factors for Ral have been identified, including members of the RalGDS family …
[引用][C] Hyperhomocysteinemia due to folate deficiency. Impact on haemostasis and vascular biology
LMS Ebbesen - UGESKRIFT FOR LAEGER, 2003 - DEN ALM DANSKE …