Fibroblast pathology in inflammatory diseases
Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …
Promising therapeutic targets for treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …
Fc-engineering for modulated effector functions—improving antibodies for cancer treatment
The majority of monoclonal antibody (mAb) therapeutics possess the ability to engage
innate immune effectors through interactions mediated by their fragment crystallizable (Fc) …
innate immune effectors through interactions mediated by their fragment crystallizable (Fc) …
Targeting the CCL2/CCR2 axis in cancer immunotherapy: one stone, three birds?
L Fei, X Ren, H Yu, Y Zhan - Frontiers in immunology, 2021 - frontiersin.org
CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …
CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis
H Raghu, CM Lepus, Q Wang, HH Wong… - Annals of the …, 2017 - ard.bmj.com
Objectives While various monocyte chemokine systems are increased in expression in
osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating …
osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating …
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for …
F Bachelerie, A Ben-Baruch, AM Burkhardt… - Pharmacological …, 2014 - Elsevier
Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …
Synovial tissue research: a state-of-the-art review
The synovium is the major target tissue of inflammatory arthritides such as rheumatoid
arthritis. The study of synovial tissue has advanced considerably throughout the past few …
arthritis. The study of synovial tissue has advanced considerably throughout the past few …
Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes
J Panee - Cytokine, 2012 - Elsevier
Monocyte Chemoattractant Protein-1 (MCP-1) is the first discovered and most extensively
studied CC chemokine, and the amount of studies on its role in the etiologies of obesity-and …
studied CC chemokine, and the amount of studies on its role in the etiologies of obesity-and …
T cell migration in rheumatoid arthritis
M Mellado, L Martínez-Muñoz, G Cascio… - Frontiers in …, 2015 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
in joints, associated with synovial hyperplasia and with bone and cartilage destruction …
in joints, associated with synovial hyperplasia and with bone and cartilage destruction …
Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer
KJ Pienta, JP Machiels, D Schrijvers, B Alekseev… - Investigational new …, 2013 - Springer
Background CC-chemokine ligand 2 (CCL2) promotes tumor growth by angiogenesis,
macrophage infiltration and tumor invasion, and distant metastasis. Carlumab (CNTO 888) is …
macrophage infiltration and tumor invasion, and distant metastasis. Carlumab (CNTO 888) is …