Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

Z Megyesfalvi, CM Gay, H Popper… - CA: a cancer journal …, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity.
It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority …

Emerging therapies targeting the delta-like ligand 3 (DLL3) in small cell lung cancer

CM Rudin, M Reck, ML Johnson, F Blackhall… - Journal of Hematology & …, 2023 - Springer
Small cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma with a poor
prognosis. Initial responses to standard-of-care chemo-immunotherapy are, unfortunately …

IL-18–secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models

JE Jaspers, JF Khan, WD Godfrey… - The Journal of …, 2023 - Am Soc Clin Investig
Patients with small cell lung cancer (SCLC) generally have a poor prognosis and a median
overall survival of only about 13 months, indicating the urgent need for novel therapies …

[HTML][HTML] Targeting the Notch signaling pathway and the Notch ligand, DLL3, in small cell lung cancer

H Zhang, Y Yang, X Li, X Yuan, Q Chu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Small cell lung cancer (SCLC) is a highly aggressive and poorly differentiated cancer with
high-grade neuroendocrine (NE) features, accounting for approximately 15% of all lung …

Small cell lung cancer: emerging targets and strategies for precision therapy

SR Patel, M Das - Cancers, 2023 - mdpi.com
Simple Summary Small cell lung cancer (SCLC) remains a difficult-to-treat disease and is
associated with a poor prognosis in most patients. Discovering biomarkers and developing …

Targeting cancer stem cell pathways for lung cancer therapy

M Liu, H Wu, C Xu - Current Opinion in Oncology, 2023 - journals.lww.com
The current review elucidates the characteristics and related regulating pathways of lung
CSCs from essential to preclinical research. We retrospectively introduce an update on the …

Advancing immunotherapy in small cell lung cancer

JW Carlisle, T Leal - Cancer, 2023 - Wiley Online Library
Small cell lung cancer (SCLC) is a rapidly progressive neuroendocrine carcinoma that, until
recently, had a very small armamentarium of effective treatments. Advances in DNA …

Canadian consensus recommendations on the management of extensive-stage small-cell lung cancer

BL Melosky, NB Leighl, D Dawe, N Blais… - Current …, 2023 - mdpi.com
Small-cell lung cancer (SCLC) is an aggressive, neuroendocrine tumour with high relapse
rates, and significant morbidity and mortality. Apart from advances in radiation therapy …

Immunotherapy for small cell lung cancer: the current state and future trajectories

M Qiang, H Liu, L Yang, H Wang, R Guo - Discover Oncology, 2024 - Springer
Small cell lung cancer (SCLC) constitutes approximately 10% to 15% of all lung cancer
diagnoses and represents a pressing global public health challenge due to its high mortality …

Tarlatamab: new star on the horizon for small-cell lung cancer?

S Tendler, CM Rudin - Journal of Clinical Oncology, 2023 - ascopubs.org
Small-cell lung cancer (SCLC) comprises approximately 14% of all lung cancer diagnoses
and is exceptionally lethal. Approximately two thirds of patients with SCLC present with extra …