G protein-coupled receptors (GPCRs) are the largest group of receptors involved in cellular
signaling across the plasma membrane and a major class of drug targets. The canonical …

Adenosine is one of the most ancient signaling molecules and has receptors in both animals
and plants. In mammals there are four specific receptors, A 1, A 2A, A 2B, and A 3, which …

Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that
can be attained by ligand‐binding or protein–protein interactions with another GPCR. We …

The therapeutic benefits of the current medications for patients with psychiatric disorders
contrast with a great variety of adverse effects. The endocannabinoid system (ECS) …

Membrane trafficking processes regulate G protein–coupled receptor (GPCR) activity.
Although class A GPCRs are capable of activating G proteins in a monomeric form, they can …

Heavy cannabis use (HCU) is frequently associated with a plethora of cognitive,
psychopathological and sensorimotor phenomena. Although HCU is frequent, specific …

AG protein-coupled receptor heteromer that fulfills the established criteria for its existence in
vivo is the complex between adenosine A2A (A2AR) and dopamine D2 (D2R) receptors …

The striatal dopamine D 2 receptor (D 2 R) is generally accepted to be involved in positive
symptoms of schizophrenia and is a main target for clinically used antipsychotics. D 2 R are …

Abstract Endocannabinoid (eCB) and serotonin (5-HT) neuromodulatory systems work both
independently and together to finely orchestrate neuronal activity throughout the brain to …

The study of psychiatric and neurological diseases requires the substrate in which the
disorders occur, that is, the nervous tissue. Currently, several types of human bio-specimens …