[HTML][HTML] Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the …

A Hinrichs, B Kessler, M Kurome, A Blutke, E Kemter… - Molecular …, 2018 - Elsevier
Objective Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused
by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a …

[HTML][HTML] Analysis of the IGF-system in milk from farm animals–Occurrence, regulation, and biomarker potential

Z Meyer, C Höflich, E Wirthgen, S Olm… - Growth Hormone & IGF …, 2017 - Elsevier
IGFs and IGF-binding proteins (IGFBPs) are abundantly present in milk and in dairy
products. Compared to the IGFs, the IGFBP have received less attention in milk, although …

Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice

A Kammel, S Saussenthaler, M Jähnert… - Human molecular …, 2016 - academic.oup.com
Obesity and ectopic fat disposition are risk factors for metabolic disease. Recent data
indicate that IGFBP2 expression in liver is epigenetically inhibited during hepatic steatosis …

Role of PTHrP (1‐34) pulse frequency versus pulse duration to enhance mesenchymal stromal cell chondrogenesis

J Fischer, M Ortel, S Hagmann… - Journal of Cellular …, 2016 - Wiley Online Library
Generation of phenotypically stable, articular chondrocytes from mesenchymal stromal cells
(MSCs) is still an unaccomplished task, with formation of abundant, hyaline extracellular …

[HTML][HTML] Glucose metabolism and the somatotropic axis in dairy cows after abomasal infusion of essential fatty acids together with conjugated linoleic acid during late …

L Vogel, M Gnott, C Kröger-Koch, S Görs… - Journal of dairy …, 2021 - Elsevier
Sufficient glucose availability is crucial for exploiting the genetic potential of milk production
during early lactation, and endocrine changes are mainly related to repartitioning of nutrient …

[HTML][HTML] Effect of maternal supplementation with essential fatty acids and conjugated linoleic acid on metabolic and endocrine development in neonatal calves

KL Uken, L Vogel, M Gnott, S Görs, CT Schäff… - Journal of dairy …, 2021 - Elsevier
We tested the hypothesis that the maternal supply of essential fatty acids (EFA), especially α-
linolenic acid, and conjugated linoleic acid (CLA), affects glucose metabolism, the endocrine …

Phosphoproteomic analysis of subcutaneous and omental adipose tissue reveals increased lipid turnover in dairy cows supplemented with conjugated linoleic acid

JR Daddam, HM Hammon, A Tröscher, L Vogel… - International journal of …, 2021 - mdpi.com
Phosphoproteomics is a cutting-edge technique that can be utilized to explore adipose
tissue (AT) metabolism by quantifying the repertoire of phospho-peptides (PP) in AT. Dairy …

Increased concentrations of insulin-like growth factor binding protein (IGFBP)-2, IGFBP-3, and IGFBP-4 are associated with fetal mortality in pregnant cows

K Mense, J Heidekorn-Dettmer, E Wirthgen… - Frontiers in …, 2018 - frontiersin.org
Insulin-like growth factors (IGFs) play a critical role in fetal growth, and components of the
IGF system have been associated with fetal growth restriction in women. In human …

[HTML][HTML] Effects of a combined essential fatty acid and conjugated linoleic acid abomasal infusion on metabolic and endocrine traits, including the somatotropic axis, in …

S Haubold, C Kröger-Koch, A Tuchscherer… - Journal of dairy …, 2020 - Elsevier
The objective of this study was to test the effects of essential fatty acids (EFA), particularly α-
linolenic acid (ALA), and conjugated linoleic acid (CLA) supplementation on metabolic and …

Interference of stress with the somatotropic axis in pigs–lights on new biomarkers

E Wirthgen, M Kunze, S Goumon, C Walz, C Höflich… - Scientific reports, 2017 - nature.com
The acceptance of animal products is increasingly associated with standardized animal
welfare, which relates to appropriate animal husbandry from birth to slaughter. In particular …