“Don't Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer's disease and other tauopathies
Phosphorylation is one of the most prevalent post-translational modifications found in
aggregated tau isolated from Alzheimer's disease (AD) patient brains. In tauopathies like …
aggregated tau isolated from Alzheimer's disease (AD) patient brains. In tauopathies like …
Neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: Clinical, pathological and neuroimaging evidence
XY Tai, B Bernhardt, M Thom… - Neuropathology and …, 2018 - Wiley Online Library
Cognitive decline is increasingly described as a co‐morbidity of temporal lobe epilepsy
(TLE). Mechanisms underlying cognitive impairment are not fully understood despite …
(TLE). Mechanisms underlying cognitive impairment are not fully understood despite …
Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study
Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-
analysis, we integrated neuroimaging and connectome analysis to identify network …
analysis, we integrated neuroimaging and connectome analysis to identify network …
Structural brain changes in medically refractory focal epilepsy resemble premature brain aging
Objective We used whole brain T1-weighted MRI to estimate the age of individuals with
medically refractory focal epilepsy, and compared with individuals with newly diagnosed …
medically refractory focal epilepsy, and compared with individuals with newly diagnosed …
Functional connectome contractions in temporal lobe epilepsy: Microstructural underpinnings and predictors of surgical outcome
Objective Temporal lobe epilepsy (TLE) is the most common drug‐resistant epilepsy in
adults. Although it is commonly related to hippocampal pathology, increasing evidence …
adults. Although it is commonly related to hippocampal pathology, increasing evidence …
Propionate and Alzheimer's disease
J Killingsworth, D Sawmiller, RD Shytle - Frontiers in aging …, 2021 - frontiersin.org
Propionate, a short-chain fatty acid, serves important roles in the human body. However, our
review of the current literature suggests that under certain conditions, excess levels of …
review of the current literature suggests that under certain conditions, excess levels of …
Can the retinal ganglion cell layer (GCL) volume be a new marker to detect neurodegeneration in bipolar disorder?
A Kalenderoglu, A Sevgi-Karadag, M Celik… - Comprehensive …, 2016 - Elsevier
Purpose The aim of this study was to compare the ganglion cell layer (GCL) volume and
retinal nerve fiber layer (RNFL) thickness in bipolar patients and controls using optic …
retinal nerve fiber layer (RNFL) thickness in bipolar patients and controls using optic …
Topographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy
Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily a limbic
network disorder associated with predominant unilateral hippocampal pathology. Structural …
network disorder associated with predominant unilateral hippocampal pathology. Structural …
Progression of gray matter atrophy in seizure‐free patients with temporal lobe epilepsy
Objectives To investigate the presence and progression of gray matter (GM) reduction in
seizure‐free patients with temporal lobe epilepsy (TLE). Methods We enrolled 39 …
seizure‐free patients with temporal lobe epilepsy (TLE). Methods We enrolled 39 …
Community-informed connectomics of the thalamocortical system in generalized epilepsy
Objective To study the intrinsic organization of the thalamocortical circuitry in patients with
generalized epilepsy with tonic-clonic seizures (GTCS) via resting-state fMRI (rs-fMRI) …
generalized epilepsy with tonic-clonic seizures (GTCS) via resting-state fMRI (rs-fMRI) …