Soils suppressive to soilborne pathogens have been identified worldwide for almost 60
years and attributed mainly to suppressive or antagonistic microorganisms. Rather than …

Actinobacteria exhibit cosmopolitan distribution since their members are widely distributed
in aquatic and terrestrial ecosystems. In the environment they play relevant ecological roles …

Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or
“orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in public databases …

The cyclic dinucleotide c-di-GMP is a signaling molecule with diverse functions in cellular
physiology. Here, we report that c-di-GMP can assemble into a tetramer that mediates the …

Background Heterologous expression of secondary metabolite gene clusters is used to
achieve increased production of desired compounds, activate cryptic gene clusters …

Direct cloning represents the most efficient strategy to access the vast number of
uncharacterized natural product biosynthetic gene clusters (BGCs) for the discovery of novel …

Environments co-contaminated with metals and organic compounds are difficult to
remediate. Actinobacteria is an important group of microorganisms found in soils, with high …

Background: Prodiginines are a large family of pigmented oligopyrrole antibiotics with
medicinal potential as immunosuppressants and antitumour agents that are produced by …

Bacterially produced secondary metabolites are used as antibiotics, anticancer drugs, and
for many other medicinal applications. The mechanisms that limit the production of these …

Streptomyces bacteria are ubiquitous in soils and are well known for producing secondary
metabolites, including antimicrobials. Increasingly, they are being isolated from plant roots …