Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …

Pharmacological interventions have been tested experimentally and clinically to prevent
hydrocephalus and avoid the need for shunting beginning in the 1950s. Clinical trials of …

Objectives: Identify the mechanism of action of thrombolytics. Describe the potential adverse
effects associated with various thrombolytic agents. Review the monitoring for patients on …

Thrombotic blockages within blood vessels give rise to critical cardiovascular disorders,
including ischemic stroke, venous thromboembolism, and myocardial infarction. The current …

Streptokinase (SK) remains a favored thrombolytic agent in the developing world as
compared to the nearly 10-fold more expensive human tissue-plasminogen activator (tPA) …

Streptokinase (SK), a plasminogen activator (PA) that converts inactive plasminogen (Pg) to
plasmin (Pm), is a protein secreted by groups A, C, and G streptococci (GAS, GCS, and …

Background: Streptokinase, one of the most widely used thrombolytic medicines, is a
favorable protein for site-specific PEGylation as it lacks any cysteine residues in its amino …

Streptokinase (SK) is a potent clot dissolver but lacks fibrin clot specificity as it activates
human plasminogen (HPG) into human plasmin (HPN) throughout the system leading to …

Background: Increase of protein purity is a serious challenge in the production of
recombinant therapeutic proteins. For this purpose, several strategies have been employed …

Background: Despite the extensive use of streptokinase in thrombolytic therapy, its
administration may have some shortcomings like allergic reactions and relatively low half …