To maintain iron homeostasis within the cell, bacteria have evolved various types of iron
acquisition systems. Ferric iron (Fe3+) is the dominant species in an oxygenated …

It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

Following nitric oxide (nitrogen monoxide) and carbon monoxide, hydrogen sulfide (or its
newer systematic name sulfane, H 2 S) became the third small molecule that can be both …

Iron/sulfur centers are key cofactors of proteins intervening in multiple conserved cellular
processes, such as gene expression, DNA repair, RNA modification, central metabolism and …

Hypochlorous acid (HOCl), the active ingredient of household bleach, is the most common
disinfectant in medical, industrial, and domestic use and plays an important role in microbial …

Mitochondrial oxidative phosphorylation (OXPHOS) sustains organelle function and plays a
central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit …

Eukaryogenesis, the origin of the eukaryotic cell, represents one of the fundamental
evolutionary transitions in the history of life on earth. This event, which is estimated to have …

The past decade has provided exciting insights into a novel class of central (small) RNA
molecules intimately involved in gene regulation. Only a small percentage of our DNA is …

Transition metal deficiency has a strong impact on the growth and survival of an organism.
Indeed, transition metals, such as iron, copper, manganese and zinc, constitute essential …

The biogenesis of iron–sulfur (Fe–S) proteins in humans is a multistage process occurring in
different cellular compartments. The mitochondrial iron–sulfur cluster (ISC) assembly …