Due to the long-term and widespread use of antibiotics in clinic, the problem of bacterial
resistance is increasingly serious, and the development of new drugs to treat drug-resistant …

The widespread use of antibiotics has made the problem of bacterial resistance increasingly
serious, and the study of new drug-resistant bacteria has become the main direction of …

Oxazolidinone is a five-member heterocyclic ring with several biological applications in
medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most …

The oxazolidinones are a new and potent class of antimicrobial agents with activity mainly
against Gram-positive strains. The commercial success of linezolid, the only FDA-approved …

The clinical success of linezolid for treating Gram-positive infections paired with the high
conservation of bacterial ribosomes predicts that if oxazolidinones were engineered to …

Tuberculosis (TB) remains a serious public health challenge, and the research and
development of new anti-TB drugs is an essential component of the global strategy to …

Oxazolidinones represent a significant class of synthetic bacterial protein synthesis
inhibitors that are primarily effective against Gram-positive bacteria. The commercial …

Methicillin‐resistant Staphylococcus aureus (MRSA) has developed numerous mechanisms
of virulence and strategies to evade the human immune system, and it can be transmitted …

A number of linezolid-like oxazolidino-sulfonamides (7a–y and 8a–b) were designed and
synthesized with a view to develop antimicrobial agents with improved properties. Most of …

A biocatalytic approach for the synthesis of metaxalone and its analogues was developed
based on the reaction of epoxides and cyanate catalyzed by halohydrin dehalogenase …