Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Background Recent research on the implications of gut microbiota on brain functions has
helped to gather important information on the relationship between them. Pathogenesis of …

The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …

Lung cancer with the highest mortality poses a great threat to human health. Ferroptosis
therapy has recently been raised as a promising strategy for lung cancer treatment by …

Ulcerative colitis (UC), an etiologically complicated and relapsing gastrointestinal disease, is
characterized by the damage of mucosal epithelium and destruction of the intestinal …

Vitiligo is a common chronic acquired pigmentation disorder characterized by loss of
pigmentation. Among various hypotheses proposed for the pathogenesis of vitiligo, oxidative …

Ferroptosis is a form of regulated cell death that is triggered by iron accumulation and lipid
peroxidation. Although plasma membrane injuries represent an important event in cell …

Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

Protein kinase RNA‐like ER kinase (PERK) is an endoplasmic reticulum (ER) stress sensor
that responds to the accumulation of misfolded proteins. Once activated, PERK initiates …

The concentration of Ca 2+ in the endoplasmic reticulum (ER) is critically important for
maintaining its oxidizing environment as well as for maintaining luminal ATP levels required …