Lewis acids play a major role in all areas of chemistry. For a long time, toxic, corrosive and
oxidizing SbF5 was considered as the strongest Lewis acid known. Lately, species …

Herein we describe the development of a catalytic enantioselective alkynylogous
Mukaiyama aldol reaction. The reaction is catalyzed by a newly designed chiral …

We propose to construct electron correlation methods that are scalable in both molecule size
and aggregated parallel computational power, in the sense that the total elapsed time of a …

A palladium‐catalyzed carbonylative approach for the direct conversion of (hetero) aryl
bromides into their α, α‐bis (trifluoromethyl) carbinols is described, and it employs only …

An organocatalytic asymmetric synthesis of δ‐amino‐β‐ketoester derivatives has been
developed. A chiral disulfonimide (DSI) serves as a highly efficient precatalyst for a …

A complementary dual carbonyl activation strategy for the synthesis of polycyclic alkaloids
has been developed. Successful applications include the synthesis of tetracyclic alkaloids …

Tetratrifylpropene (TTP) has been developed as a highly acidic, allylic C–H acid for
Brønsted and Lewis acid catalysis. It can readily be obtained in two steps and consistently …

The total synthesis of the flagship Strychnos indole alkaloid, strychnine, has been
accomplished. The developed synthetic sequence features a novel vinylogous 1, 4‐addition …

The Mukaiyama aldol reaction is a widely applied carbon–carbon bond forming reaction.
However, despite numerous well‐established methods using aldehydes as acceptors, only …

Mukaiyama–Mannich reactions of ester enolate equivalents with aldimines have been
elegantly used for the asymmetric synthesis of β‐amino acids; nevertheless, the …