The global epidemic of Alzheimer disease (AD) is worsening, and no approved treatment
can revert or arrest progression of this disease. AD pathology is characterized by the …

The endosomal-lysosomal system is made up of a set of intracellular membranous
compartments that dynamically interconvert, which is comprised of early endosomes …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

The identification of genetic causes for Mendelian disorders has been based on the
collection of multi-incident families, linkage analysis, and sequencing of genes in candidate …

Recent genome-wide association studies have linked common variants in the human
genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants …

The endosomal network comprises an interconnected network of membranous
compartments whose primary function is to receive, dissociate, and sort cargo that originates …

A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …

The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …