Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Increasing evidence from animal and in vitro studies indicates that n− 3 fatty acids,
especially the long-chain polyunsaturated fatty acids eicosapentaenoic acid and …

Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …

Key molecular lesions in colorectal and other cancers cause β-catenin-dependent
transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an …

Protein kinase C (PKC) comprises a family of serine/threonine kinases that are involved in
the transduction of signals for cell proliferation, differentiation, apoptosis and angiogenesis …

Activation of protein kinase Cβ (PKCβ) has been repeatedly implicated in tumor-induced
angiogenesis. The PKCβ-selective inhibitor, Enzastaurin (LY317615. HCl), suppresses …

Spatial and temporal organization of signal transduction is essential in determining the
speed and precision by which signaling events occur. Adaptor proteins are key to organizing …

PKC family consist of a number of serine-threonine kinases which are divided into three
groups based on their activating factors. PKCs have been linked to carcinogenesis since …

The annexins are family of calcium-regulated phospholipid-binding proteins with diverse
roles in cell biology. Individual annexins have been implicated in tumour development and …