Cyclic nucleotides [eg, cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP)] are ubiquitous second messengers that affect multiple cell …

Increased intracellular cAMP concentration plays a well established role in leukemic cell
maturation. We previously reported that U937 cells stimulated by H2 receptor agonists …

MRP4 transports multiple endogenous and exogenous substances and is critical not only for
detoxification but also in the homeostasis of several signaling molecules. Its dysregulation …

Multidrug resistance–associated protein 4 (MRP4, also known as Abcc4) regulates
intracellular levels of cAMP and cGMP in arterial SMCs. Here, we report our studies of the …

Ovarian cancer is the main cause of death from gynaecological malignancies. In spite of the
efficacy of platinum‐paclitaxel treatment in patients with primary epithelial ovarian …

Nasal-type natural killer/T-cell (NK/T-cell) lymphomas are subtypes of non-Hodgkin's
lymphoma (NHL), which are typically more clinically aggressive. There is, however relatively …

Background The pathogenesis of colorectal neoplasia is still unresolved but has been
associated with alterations in epithelial clearance of xenobiotics and metabolic waste …

ATP-binding cassette (ABC) transporters are a large family of proteins implicated in
physiological cellular functions. Selected components of the family play a well-recognized …

The ATP-binding cassette transporter MRP4 (encoded by ABCC4) regulates membrane
cyclic nucleotides concentrations in arterial cells including smooth muscle cells …

Cyclic nucleotides (eg, cAMP and cGMP) are ubiquitous second messengers that affect
multiple cell functions including vascular tone and vascular cell proliferation. After …