Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

Viruses and intracellular bacterial pathogens (IBPs) have in common the need of suitable
host cells for efficient replication and proliferation during infection. In human infections, the …

HIF is a transcription factor that plays an essential role in the cellular response to low
oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In …

Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases
(HKs), play crucial roles. Cancer cells are characterized by specific expression levels of …

Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life.
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …

Human immunodeficiency virus-associated neurological disorders (HANDs) affect the
majority of AIDS patients and are a significant problem among HIV-1-infected individuals …

Activation of the immune system occurs in response to the recognition of foreign antigens
and receipt of optimal stimulatory signals by immune cells, a process that requires energy …

Chronic immune activation and inflammation are hallmarks of HIV-1 infection and a major
cause of serious non-AIDS events in HIV-1-infected individuals on antiretroviral treatment …

The calcium-permeable ion channel TRPM2 is highly expressed in a number of cancers. In
neuroblastoma, full-length TRPM2 (TRPM2-L) protected cells from moderate oxidative stress …

Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART)
interruption are urgently needed. Such biomarkers can improve the safety of analytic …