Targeting Persistent Neuroinflammation after Hypoxic-Ischemic Encephalopathy—Is Exendin-4 the Answer?

KQ Zhou, SK Dhillon, L Bennet, AJ Gunn… - International journal of …, 2022 - mdpi.com
Hypoxic-ischemic encephalopathy is brain injury resulting from the loss of oxygen and blood
supply around the time of birth. It is associated with a high risk of death or disability. The only …

[HTML][HTML] Outcome at early school age and adolescence after hypothermia-treated hypoxic–ischaemic encephalopathy: an observational, population-based study

KR Grossmann, ME Westblad, M Blennow… - Archives of Disease in …, 2023 - fn.bmj.com
Objective We aimed to describe long-term outcomes following hypoxic–ischaemic
encephalopathy (HIE) treated with therapeutic hypothermia (TH). Design Prospective …

[HTML][HTML] Mesenchymal Stromal Cell Therapy for Hypoxic Ischemic Encephalopathy: Future directions for Combination Therapy with Hypothermia and/or Melatonin

A Mintoft, A Vallatos, NJ Robertson - Seminars in Perinatology, 2024 - Elsevier
Hypoxic ischemic encephalopathy (HIE) remains a leading cause of neonatal mortality and
lifelong disability across the world. While therapeutic hypothermia (HT) is beneficial, it is only …

Neuroprotective Effect of Clemastine Improved Oligodendrocyte Proliferation through the MAPK/ERK Pathway in a Neonatal Hypoxia Ischemia Rat Model

ME Bernis, C Hakvoort, E Nacarkucuk… - … journal of molecular …, 2024 - pmc.ncbi.nlm.nih.gov
Neonatal hypoxic-ischemic encephalopathy is the most common cause of long-term
disability in term neonates, and white matter injury is the primary cause of cerebral palsy …

Brain volumes and functional outcomes in children without cerebral palsy after therapeutic hypothermia for neonatal hypoxic‐ischaemic encephalopathy

APC Spencer, R Lee‐Kelland… - … Medicine & Child …, 2023 - Wiley Online Library
Aim To investigate whether brain volumes were reduced in children aged 6 to 8 years
without cerebral palsy, who underwent therapeutic hypothermia for neonatal hypoxic …

Mammillary body abnormalities and cognitive outcomes in children cooled for neonatal encephalopathy

APC Spencer, MH Lequin, LS De Vries… - … Medicine & Child …, 2023 - Wiley Online Library
Aim To evaluate mammillary body abnormalities in school‐age children without cerebral
palsy treated with therapeutic hypothermia for neonatal hypoxic–ischaemic encephalopathy …

MRI predictors of long-term outcomes of neonatal hypoxic ischaemic encephalopathy: a primer for radiologists

SC Hung, YF Tu, SE Hunter… - British Journal of …, 2024 - academic.oup.com
This review aims to serve as a foundational resource for general radiologists, enhancing
their understanding of the role of Magnetic Resonance Imaging (MRI) in early …

Volumetric apparent diffusion coefficient histogram analysis in term neonatal asphyxia treated with hypothermia

T Seber, T Uylar Seber, A Özdemir… - British Journal of …, 2024 - academic.oup.com
Objectives Our aim is to estimate the long-term neurological sequelae and prognosis in term
neonatal asphyxia treated with hypothermia via volumetric apparent diffusion coefficient …

Diffusion Tensor Imaging to Predict Neurodevelopmental Impairment in Infants after Hypoxic–Ischemic Injury

C Tabacaru, A Braimah, B Kline-Fath… - American Journal of …, 2024 - thieme-connect.com
Objective Magnetic resonance imaging (MRI) is the standard of care for evaluation of brain
injury after hypoxic–ischemic encephalopathy (HIE) in term newborns. This study utilizes …

Functional brain connectivity in early adolescence after hypothermia-treated neonatal hypoxic-ischemic encephalopathy

G Håkansson, K Robertsson Grossmann, U Ådén… - medRxiv, 2024 - medrxiv.org
Aim: Neonatal hypoxic-ischemic encephalopathy (HIE) injures the infant brain during the
basic formation of the developing functional connectome. This study aimed to investigate …