Abstract AKT/PKB (protein kinase B) kinases mediate signaling pathways downstream of
activated tyrosine kinases and phosphatidylinositol 3-kinase. AKT kinases regulate diverse …

Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …

The AKT1, AKT2, and AKT3 kinases have emerged as critical mediators of signal
transduction pathways downstream of activated tyrosine kinases and phosphatidylinositol 3 …

Neuroblastoma (NB) is the most common and deadly solid tumour in children. Despite the
development of new treatment options for high-risk NB, over half of patients relapse and five …

Abstract A t (2; 5) chromosomal translocation resulting in expression of an oncogenic kinase
fusion protein known as nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) has been …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease
affecting motor neurons. Hexanucleotide (GGGGCC) repeat expansions in a non-coding …

The anaplastic lymphoma kinase (ALK) gene is characteristically translocated in Anaplastic
Large Cell Lymphomas (ALCL) and the juxtaposion of the ALK gene to multiple partners …

Classical Hodgkin lymphoma (cHL) and anaplastic lymphoma kinase-positive, anaplastic
large cell lymphoma (ALK+ ALCL) are B and T cell lymphomas respectively, which express …