Early human embryonic development: Blastocyst formation to gastrulation
J Rossant, PPL Tam - Developmental cell, 2022 - cell.com
There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
Stem-cell-based embryo models for fundamental research and translation
Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
Mechanisms of human embryo development: from cell fate to tissue shape and back
MN Shahbazi - Development, 2020 - journals.biologists.com
Gene regulatory networks and tissue morphogenetic events drive the emergence of shape
and function: the pillars of embryo development. Although model systems offer a window …
and function: the pillars of embryo development. Although model systems offer a window …
Self-organization of stem cells into embryos: a window on early mammalian development
Embryonic development is orchestrated by robust and complex regulatory mechanisms
acting at different scales of organization. In vivo studies are particularly challenging for …
acting at different scales of organization. In vivo studies are particularly challenging for …
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …
Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
E Sempou, V Kostiuk, J Zhu, M Cecilia Guerra… - Nature …, 2022 - nature.com
Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic
development and adult tissue homeostasis. Improving our understanding of this transition …
development and adult tissue homeostasis. Improving our understanding of this transition …
Stem-cell-based human and mouse embryo models
M Bao, J Cornwall-Scoones… - Current opinion in genetics …, 2022 - Elsevier
Synthetic embryology aims to develop embryo-like structures from stem cells to provide new
insight into early stages of mammalian development. Recent advances in synthetic …
insight into early stages of mammalian development. Recent advances in synthetic …
Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells
I Heemskerk, K Burt, M Miller, S Chhabra, MC Guerra… - Elife, 2019 - elifesciences.org
During embryonic development, diffusible signaling molecules called morphogens are
thought to determine cell fates in a concentration-dependent way. Yet, in mammalian …
thought to determine cell fates in a concentration-dependent way. Yet, in mammalian …
Stem cell bioengineering: building from stem cell biology
New fundamental discoveries in stem cell biology have yielded potentially transformative
regenerative therapeutics. However, widespread implementation of stem-cell-derived …
regenerative therapeutics. However, widespread implementation of stem-cell-derived …
Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling
Human primordial germ cells (hPGCs) form around the time of implantation and are the
precursors of eggs and sperm. Many aspects of hPGC specification remain poorly …
precursors of eggs and sperm. Many aspects of hPGC specification remain poorly …